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Clinical trials for glioblastoma

Glioblastoma is an area of intense research, and trials range from new drugs to devices and vaccines. Study sites are listed on each record, and for a study open at only a few centers, travel is often the deciding factor, so it is worth checking where each one is running.

321 recruiting trials. Showing a sample.

  • recruitingPhase 1, Phase 2NCT06622434

    New Adjuvant Vaccine in Glioblastoma, a Phase 1/2a Study

    This phase I/II trial evaluates the safety and the immunological efficacy of a cancer vaccine against 2 glioma-associated antigens in newly-diagnosed glioblastomas. The objectives of this study are as follows: Primary objective * phase 1: * to assess the maximum tolerated d...

    Listed by the study for Newly Diagnosed Glioblastoma. Record updated 2026-06-11.

    Sponsored by Assistance Publique - Hôpitaux de ParisFull details on ClinicalTrials.gov →
  • recruitingNCT07552467

    Sub-topic Four: Clinical Translation of Original Radioactive Drugs for Precision Diagnosis and Treatment of Gastrointestinal Tumors -Clinical Application Value of PET Imaging Targeting LRRC15 in Malignant Tumors

    This project utilizes LRRC15-specific targeted PET radiotracers to perform PET/MR or PET/CT imaging on healthy volunteers and patients with clinically suspected or confirmed malignancies characterized by high LRRC15 expression-including pancreatic cancer, breast cancer, lung c...

    Listed by the study for Glioblastoma. Record updated 2026-04-27.

    Sponsored by Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyFull details on ClinicalTrials.gov →
  • recruitingNANCT05990244

    Magnetic Resonance Elastography in Glioma: Exploring Tumor Stiffness and Adhesion

    this study will investigate the relationship between tumor stiffness and adhesion in gliomas using MRE. By utilizing preoperative MRE and Intraoperative neuronavigation, followed by comprehensive molecular pathology analysis, we aim to explore the correlation of tumor stiffnes...

    Listed by the study for Glioblastoma. Record updated 2025-12-02.

    Sponsored by Shengjing HospitalFull details on ClinicalTrials.gov →
  • recruitingPhase 1, Phase 2NCT06630260

    5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours

    The purpose of this clinical trial is to evaluate the safety and tolerability of avutometinib and defactinib and to determine the preliminary antitumour activity of avutometinib and defactinib administered at the recommended Phase 2 dose (RP2D). In the Phase 1b of this study p...

    Listed by the study for Glioblastoma Multiforme (GBM). Record updated 2026-01-21.

    Sponsored by Institute of Cancer Research, United KingdomFull details on ClinicalTrials.gov →
  • recruitingPhase 1NCT03383978

    Intracranial Injection of NK-92/5.28.z Cells in Combination With Intravenous Ezabenlimab in Patients With Recurrent HER2-positive Glioblastoma

    The main objective of this clinical study is to evaluate the safety and tolerability of NK-92/5.28.z and to determine the maximum tolerated dose or maximum feasible dose (MFD). Recommended phase 2 doses both for intraoperative injections only (RP2Diio) and repetitive injection...

    Listed by the study for Glioblastoma. Record updated 2026-04-23.

    Sponsored by Johann Wolfgang Goethe University HospitalFull details on ClinicalTrials.gov →
  • recruitingNCT06118723

    The SUPRAMAX Study: Supramaximal Resection Versus Maximal Resection for High-Grade Glioma Patients (ENCRAM 2201)

    A greater extent of resection of the contrast-enhancing (CE) tumor part has been associated with improved outcomes in high-grade glioma patients. Recent results suggest that resection of the non-contrast-enhancing (NCE) part might yield even better survival outcomes (supramaxi...

    Listed by the study for Glioblastoma. Record updated 2024-02-22.

    Sponsored by Jasper GerritsenFull details on ClinicalTrials.gov →
  • recruitingNCT07411690

    Analysis of Cerebrospinal Fluid Leakage After Surgery for Intracranial Tumors

    Cerebrospinal fluid is a clear fluid that surrounds and protects the brain. During surgery for brain tumors, neurosurgeons often need to open the covering of the brain (the dura) to reach the tumor. At the end of the operation, this covering is carefully closed again. In some ...

    Listed by the study for Glioblastoma. Record updated 2026-05-22.

    Sponsored by Medical University of WarsawFull details on ClinicalTrials.gov →
  • recruitingPhase 2NCT06356883

    Intraarterial Carboplatin + Caelyx vs Intraarterial Carboplatin + Etoposide Phosphate for Progressing Glioblastoma

    The standard of care for glioblastoma (GBM) treatment involves maximal resection followed by concomitant radiotherapy and temozolomide. Progression-free survival (PFS) with this treatment is only 6.9 months and relapse is inevitable. At relapse, there is no consensus regarding...

    Listed by the study for Glioblastoma Multiforme. Record updated 2025-08-07.

    Sponsored by Université de SherbrookeFull details on ClinicalTrials.gov →
  • recruitingNCT07173829

    A Study to Better Understand the Biological and Molecular Mechanisms Involved in Glioblastoma Recurrence and Progression

    BORDEAUX-GLIO is a prospective, monocentric study which will describe the molecular, immune and metabolic pathways involved in the progression and relapse of glioblastoma, using blood and tumor samples from patients who have undergone surgery for newly diagnosed or recurrent g...

    Listed by the study for Glioblastoma. Record updated 2026-08-07.

    Sponsored by University Hospital, BordeauxFull details on ClinicalTrials.gov →
  • recruitingPhase 1NCT07464925

    A Phase 1 Safety and Dose Finding Study of GLIX1 in Adults With Recurrent or Progressive High-grade Glioma

    This is an open-label, multicenter dose-escalation study to be followed by a dose expansion to define the optimal dose of GLIX1 as monotherapy by reviewing safety and tolerability, disease characteristics and pharmacokinetic profiles and preliminary clinical activity in partic...

    Listed by the study for Glioblastoma Multiforme of Brain. Record updated 2026-07-30.

    Sponsored by Tetragon Biosciences LtdFull details on ClinicalTrials.gov →

Data from ClinicalTrials.gov, retrieved 2026-10-12. Study sponsors write and update their own records there, including the recruitment status shown here, and the U.S. government does not review or approve every study listed. A trial showing up here is not a recommendation and not a determination that anyone qualifies. Eligibility is decided by the trial's own doctors.

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Trials for other conditions

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Common questions

Is this glioblastoma trial finder really free?
Yes. You describe the situation, we search ClinicalTrials.gov and show what matches. No account, no payment, no email required. Nothing you type is saved.
Does showing up here mean the patient qualifies?
No. A listing here is not a recommendation, and the U.S. government does not review or approve every study on ClinicalTrials.gov. These are trials worth asking your care team about. Every trial has detailed eligibility criteria that the trial's own doctors evaluate, and many depend on test results and treatment history that only your medical team knows in full.
How current is this list?
The trials come directly from ClinicalTrials.gov and are refreshed daily, with the retrieval date shown under the list. Each study record is written and kept up to date by that study's own sponsor, so the recruitment status is what the sponsor last reported. Each result links to the full, live record, and the finder above always runs a fresh search when you use it.
What should I do with a trial that looks promising?
Bring it to your oncologist or care team, and mention the NCT number (the ID that starts with NCT). They can tell you whether it is a genuine fit and refer you to the trial site.

Found trials worth discussing? Keep them next to the records.

The next step is a conversation with the care team, and that goes better when the scans, labs, and trial details live in one place everyone in the family can see. That's what KeptWell is: the binder, but it understands what's inside.

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