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Clinical trials for head and neck cancer
Head and neck cancer trials often depend on HPV status and where in the head or neck the cancer started. Both shape which studies are a fit.
904 recruiting trials. Showing a sample.
- recruitingNANCT05874492
Evaluation of the Medical Benefit of Spa Therapy on Fibrosis After Radiotherapy for Breast Cancer or UADT (Upper Aerodigestive Tract) Cancer
FIBROTHERME is a comparative, controlled, randomized, multicenter and simple blinded (investigator) trial. The aim of this study is to evaluate the medical benefit in terms of quality of life on the dermatological sequelae of fibrosis 6 months after a dermatologically oriente...
Listed by the study for Head and Neck Cancer. Record updated 2026-04-13.
Sponsored by Association Francaise pour la Recherche ThermaleFull details on ClinicalTrials.gov → - recruitingNCT05517135
tReatment Individualisation By EBV stratificatiON in Nasopharyngeal Carcinoma: an Umbrella Platform Study (RIBBON-Umbrella)
This is a prospective platform study that will investigate the outcomes of patients with locoregionally-advanced nasopharyngeal carcinoma (LA-NPC) or recurrent-metastatic nasopharyngeal carcinoma (RM-NPC) who are assigned to treatment arms of different chemotherapy sequencing ...
Listed by the study for Nasopharyngeal Carcinoma. Record updated 2024-09-19.
Sponsored by National Cancer Centre, SingaporeFull details on ClinicalTrials.gov → - recruitingNCT04099290
Circulating Tumor DNA (ctDNA) in Locally Advanced Head and Neck Squamous Cell Carcinoma
Circulating tumor DNA (ctDNA) is a blood-based test that measures dying or dead cancer cells that are already circulating in the blood. In this study, the investigators will enroll patients who are planning to receive surgery to remove their head and neck cancer. The investiga...
Listed by the study for Head and Neck Neoplasm. Record updated 2026-02-06.
Sponsored by UNC Lineberger Comprehensive Cancer CenterFull details on ClinicalTrials.gov → - recruitingNANCT07718620
HPV-associated Oropharyngeal Carcinoma (HPV-OPC)
This study focuses on the longitudinal monitoring of HPV infection in patients with head and neck cancers, particularly oropharyngeal carcinoma (OPC), using a new electrochemical detection method. This method has already been successfully developed and validated for cervical c...
Listed by the study for Oropharyngeal Carcinoma (OPC). Record updated 2026-07-22.
Sponsored by Masaryk Memorial Cancer InstituteFull details on ClinicalTrials.gov → - recruitingPhase 2NCT07465276
Neoadjuvant Ficerafusp Alfa With Pembrolizumab in Resectable SCC
This trial is to evaluate the safety and efficacy of ficerafusp alfa in combination with pembrolizumab prior to surgical resection in participants with resectable, high-risk, locoregionally advanced, PD-L1-positive squamous cell carcinoma of the head and neck (HNSCC). The nam...
Listed by the study for Head and Neck Squamous Cell Carcinoma (HNSCC). Record updated 2026-03-27.
Sponsored by Dana-Farber Cancer InstituteFull details on ClinicalTrials.gov → - recruitingNANCT05889091
A Study of the Use of Fat Flap Reconstruction to Reduce Neck Injury After Cancer Treatment
The purpose of this study is to find out whether the fat ALT flap procedure is a safe and practical option for reducing neck morbidity in HNSCC patients following cancer treatment of the neck. Neck morbidity after radiation therapy and surgery includes difficulty swallowing, n...
Listed by the study for Head and Neck Squamous Cell Carcinoma. Record updated 2026-06-03.
Sponsored by Memorial Sloan Kettering Cancer CenterFull details on ClinicalTrials.gov → - recruitingNANCT03385720
Submandibular Gland Preservation in Neck Dissection
Trial design: a randomized controlled trial. Eligibility criteria for participants: patients with primary early stage oral squamous cell carcinoma. Exclusion criteria: cancer of the floor of the mouth. Interventions: submandibular gland is preserved during neck dissection fo...
Listed by the study for Oral Cancer. Record updated 2023-03-30.
Sponsored by Guang-Yan YuFull details on ClinicalTrials.gov → - recruitingNCT06706973
Profiling and Targeting Epigenetic Marks to Improve Diagnosis and Therapeutic Approaches in Head and Neck Cancer
Investigators have recently shown that epigenetic remodelling enzymes, such as HDAC inhibitors, are feasible drugs in HNC (8, 9). Preliminary data are indicating some deregulated epigenetics marks suggesting the corresponding histone modifiers as possible targets for the treat...
Listed by the study for Head and Neck Cancer. Record updated 2024-11-27.
Sponsored by European Institute of OncologyFull details on ClinicalTrials.gov → - recruitingPhase 3NCT05941741
IC Plus Low-dose Radiation Plus Cadonilimab in LANPC
This is a multi-center, open-label, randomized controlled phase III clinical trial in primary diagnosed loco-regionally advanced nasopharyngeal carcinoma (NPC) patients. The purpose of this study is to evaluate the efficacy of induction chemotherapy (IC) combined with low-dose...
Listed by the study for Nasopharyngeal Carcinoma. Record updated 2026-05-11.
Sponsored by Sun Yat-sen UniversityFull details on ClinicalTrials.gov →
Data from ClinicalTrials.gov, retrieved 2026-10-11. Study sponsors write and update their own records there, including the recruitment status shown here, and the U.S. government does not review or approve every study listed. A trial showing up here is not a recommendation and not a determination that anyone qualifies. Eligibility is decided by the trial's own doctors.
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Add whatever you know: an age, a city, a mutation from a pathology report. We'll narrow the list to trials that fit. Describe it in your own words.
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Common questions
- Is this head and neck cancer trial finder really free?
- Yes. You describe the situation, we search ClinicalTrials.gov and show what matches. No account, no payment, no email required. Nothing you type is saved.
- Does showing up here mean the patient qualifies?
- No. A listing here is not a recommendation, and the U.S. government does not review or approve every study on ClinicalTrials.gov. These are trials worth asking your care team about. Every trial has detailed eligibility criteria that the trial's own doctors evaluate, and many depend on test results and treatment history that only your medical team knows in full.
- How current is this list?
- The trials come directly from ClinicalTrials.gov and are refreshed daily, with the retrieval date shown under the list. Each study record is written and kept up to date by that study's own sponsor, so the recruitment status is what the sponsor last reported. Each result links to the full, live record, and the finder above always runs a fresh search when you use it.
- What should I do with a trial that looks promising?
- Bring it to your oncologist or care team, and mention the NCT number (the ID that starts with NCT). They can tell you whether it is a genuine fit and refer you to the trial site.
Found trials worth discussing? Keep them next to the records.
The next step is a conversation with the care team, and that goes better when the scans, labs, and trial details live in one place everyone in the family can see. That's what KeptWell is: the binder, but it understands what's inside.
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