Free tool · No account

Clinical trials for colorectal cancer

Colorectal cancer trials increasingly test targeted and immune therapies, some limited to tumors with specific features like MSI-high status or a KRAS/BRAF mutation. A recent genomic report helps narrow the field.

1,568 recruiting trials. Showing a sample.

  • recruitingNCT05844514

    COlorectal BReath Analysis (COBRA2)

    Colorectal cancer (CRC) is the second most common cause of cancer death in the United Kingdom, with approximately 17,000 deaths per year. The five-year survival rate from CRC is only 10% when discovered at a late stage, but exceeds 90% if diagnosed early. Symptoms related to C...

    Sponsored by Imperial College LondonFull details on ClinicalTrials.gov →
  • recruitingNANCT07393906

    Colorectal Cancer Prevention Research Study: Eat Right, Screen Right

    The Eat Right, Screen Right Extension program aims to help adult learners manage nutrition risks and screening options for colorectal cancer prevention. Participants navigate through 6 tailored lessons covering user-identified, evidence-based information relevant to reducing c...

    Sponsored by University of FloridaFull details on ClinicalTrials.gov →
  • recruitingNCT06889844

    Observational Cross-reactivity Study for Colorectal Cancer Diagnosis

    The objective of this observational study is to evaluate the false positive rate of the blood test based on molecular biomarkers and risk factors. A total of 250 patients diagnosed with various cancers and gastrointestinal diseases will be enrolled. The main question to be ans...

    Sponsored by ADVANCED MARKER DISCOVERY S.L.Full details on ClinicalTrials.gov →
  • recruitingNANCT07291180

    A Feasibility Study of Mass-Based Response Drug Screening to Guide Personalized Hyperthermic Intraperitoneal Chemotherapy for High-Grade Appendiceal and Colorectal Adenocarcinoma With Peritoneal Metastasis

    This study will evaluate the role of mass-based response testing (MRT) to select and deliver personalized hyperthermic intraperitoneal chemotherapy (HIPEC) regimens to patients with peritoneal metastasis (PM) from high-grade appendiceal adenocarcinomas (HGAA) and colorectal ca...

    Sponsored by Yale UniversityFull details on ClinicalTrials.gov →
  • recruitingNCT05038358

    Tumor Immune Microenvironment Involvement in Colorectal Cancer Chemoresistance Mechanisms

    Colorectal cancer is the third most common cancer worldwide and its progression-free survival is still low, around 10 months. Thirthy to 50% of patients do not respond to chemotherapy upon initiation of treatment, suggesting that early development of chemoresistance mechanisms...

    Sponsored by University Hospital, GrenobleFull details on ClinicalTrials.gov →
  • recruitingPhase 3NCT05482516

    Evaluating Novel Therapies in ctDNA Positive GI Cancers

    This study is a non-randomized, open-label, multi-cohort, multi-site, pilot feasibility therapeutic trial. The study will enroll 20 patients across 4 cohorts (CRC, gastric, PDAC, and HCC/intra-hepatic-/extra-hepatic-, gall bladder adenocarcinomas) diagnosed with histologically...

    Sponsored by Georgetown UniversityFull details on ClinicalTrials.gov →
  • recruitingNCT06364579

    Patient Reported Outcomes (PROs) in Anal Cancer Patient Treated by Intensity Modulated Radiotherapy (IMRT).

    Radiochemotherapy is the standard treatment for neoplasms of the anal canal with excellent rates of local control and preservation of the anal sphincter. However, patients may experience a deterioration of quality of life related to sequelae of the treatment particularly at in...

    Sponsored by Fondazione Policlinico Universitario Agostino Gemelli IRCCSFull details on ClinicalTrials.gov →
  • recruitingNCT07186296

    EXoPERT EMERALD Clinical Study

    The purpose of this study is to establish a multi-center clinical repository of blood samples to support the development and evaluation of an artificial intelligence-based in vitro diagnostic software. The software analyzes surface-enhanced Raman spectroscopy (SERS) profiles o...

  • recruitingNANCT04025541

    Analysis of Circulating Tumor Markers in Blood

    The circulating tumoral biomarkers in the blood are the object of numerous researches for several decades. The potential clinical interests of these circulating biomarkers are diagnostic, prognostic, predictive of the efficiency of targeted therapies (according to the mutation...

    Sponsored by Institut du Cancer de Montpellier - Val d'AurelleFull details on ClinicalTrials.gov →
  • recruitingPhase 1, Phase 2NCT06973564

    JAB-23E73 in Adult Participants With Advanced Solid Tumors With KRAS Alteration

    This study is to evaluate the safety and tolerability of pan-KRAS inhibitor JAB-23E73 in adult participants with advanced solid tumors

    Sponsored by Jacobio Pharmaceuticals Co., Ltd.Full details on ClinicalTrials.gov →

Data from ClinicalTrials.gov, retrieved 2026-08-27. These are trials worth asking your care team about, not a determination that anyone qualifies. Eligibility is decided by the trial's own doctors.

Refine for your situation

Add whatever you know: an age, a city, a mutation from a pathology report. We'll narrow the list to trials that fit. Describe it in your own words.

Whatever you have: the diagnosis, a mutation if you know it, age, where you live.

Trials for other conditions

What we will never do with your records

This generator runs without an account, and KeptWell itself makes the same promises to every family, regardless of plan or price.

We won't sell your data.
Not to advertisers, not to data brokers, not to insurers, not to pharma, not to anyone, in any form, ever.
We won't train AI models on your records.
KeptWell does not opt in to model training. OpenAI and Anthropic do not use API inputs or outputs to train their models by default.
We won't lock you in.
You can export everything in your circle as a ZIP at any time. Cancellation is one click.

Read the full data practices →

Common questions

Is this colorectal cancer trial finder really free?
Yes. You describe the situation, we search ClinicalTrials.gov and show what matches. No account, no payment, no email required. Nothing you type is saved.
Does showing up here mean the patient qualifies?
No. These are trials worth asking your care team about. Every trial has detailed eligibility criteria that the trial's own doctors evaluate, and many depend on test results and treatment history that only your medical team knows in full.
How current is this list?
The trials come directly from ClinicalTrials.gov and are refreshed daily. Each result links to the full, live study record, and the finder above always runs a fresh search when you use it.
What should I do with a trial that looks promising?
Bring it to your oncologist or care team, and mention the NCT number (the ID that starts with NCT). They can tell you whether it is a genuine fit and refer you to the trial site.

Found trials worth discussing? Keep them next to the records.

The next step is a conversation with the care team, and that goes better when the scans, labs, and trial details live in one place everyone in the family can see. That's what KeptWell is: the binder, but it understands what's inside.

Get started

We'll email you a secure sign-in link. It works whether you're new here or already have an account.