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Clinical trials for colorectal cancer
Colorectal cancer trials increasingly test targeted and immune therapies, some limited to tumors with specific features like MSI-high status or a KRAS/BRAF mutation. A recent genomic report helps narrow the field.
1,541 recruiting trials. Showing a sample.
- recruitingPhase 3NCT03875781
Non Inferiority Study of Preoperative Chemotherapy Without Pelvic Irradiation for Rectal Cancer
This study is a non-inferiority phase III randomised trial comparing preoperative chemotherapy alone (modified FOLFIRINOX) to chemotherapy followed by chemoradiotherapy in patients with primary resectable locally advanced rectal cancer. The primary endpoint of the study is 3-y...
Listed by the study for Rectal Cancer. Record updated 2026-01-15.
Sponsored by Assistance Publique - Hôpitaux de ParisFull details on ClinicalTrials.gov → - recruitingNCT06757192
CRC Screening in Unscreened Individuals 45-54
The goal of this observational study is to understand the barriers and facilitators to completing colorectal cancer screening from the patient and community health center staff perspective. The main question it aims to answer is to identify system-level determinants of colorec...
Listed by the study for Colorectal Cancer Screening. Record updated 2025-11-13.
Sponsored by Massachusetts General HospitalFull details on ClinicalTrials.gov → - recruitingPhase 1NCT06910657
IDOV-Immune for Advanced Solid Tumors
This is a Phase I clinical trial evaluating an investigational treatment called IDOV-Immune, a type of oncolytic virus therapy, for adults with advanced solid tumors that have not responded to standard treatments. Oncolytic viruses are designed to infect and destroy cancer cel...
Listed by the study for Colorectal Cancer. Record updated 2026-08-05.
Sponsored by ViroMissile, Inc.Full details on ClinicalTrials.gov → - recruitingEARLY_Phase 1NCT07166263
Safety and Efficacy of NK510 to Treat Gastric Cancer and Colorectal Cancer
This study will evaluate the safety and efficacy of NK510 in the treatment of relapsed and refractory advanced gastric cancer and colorectal cancer.NK510 will be administered by intravenous infusion for systemic therapy and intraperitoneal perfusion therapy. The safety and eff...
Listed by the study for Colorectal Cancer. Record updated 2026-10-01.
Sponsored by Base Therapeutics (Shanghai) Co., Ltd.Full details on ClinicalTrials.gov → - recruitingNCT07552467
Sub-topic Four: Clinical Translation of Original Radioactive Drugs for Precision Diagnosis and Treatment of Gastrointestinal Tumors -Clinical Application Value of PET Imaging Targeting LRRC15 in Malignant Tumors
This project utilizes LRRC15-specific targeted PET radiotracers to perform PET/MR or PET/CT imaging on healthy volunteers and patients with clinically suspected or confirmed malignancies characterized by high LRRC15 expression-including pancreatic cancer, breast cancer, lung c...
Listed by the study for Colorectal Cancer. Record updated 2026-04-27.
Sponsored by Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyFull details on ClinicalTrials.gov → - recruitingPhase 2NCT07292298
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
Rectal cancer patients who do not achieve a complete response to standard of care chemotherapy and radiation often require surgical resection as part of curative intent therapy. This study will evaluate whether additional "focal" radiation delivered internally (rectal brachyth...
Listed by the study for Rectal Adenocarcinoma. Record updated 2026-09-02.
Sponsored by University of Colorado, DenverFull details on ClinicalTrials.gov → - recruitingNCT05517811
Pre- and Post-operative TEG Indices in Patients With or Without Adenocarcinoma Undergoing Surgical Resection
The investigators hypothesize that abnormalities in thromboelastography (TEG) parameters in patients with liver, pancreas, biliary, esophageal, colorectal, and lung adenocarcinoma can serve as biomarkers for oncologic disease burden, cancer recurrence and overall survival as w...
Listed by the study for Colorectal Cancer. Record updated 2026-08-24.
Sponsored by University of Colorado, DenverFull details on ClinicalTrials.gov → - recruitingPhase 1, Phase 2NCT05379595
A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer
The purpose of this study is to assess the anti-tumor activity of amivantamab as a monotherapy (Cohorts A, B, and C), to assess the recommended phase 2 combination dose (RP2CD) of amivantamab when added to SoC chemotherapy (Ph1b cohorts) and to characterize the safety of amiva...
Listed by the study for Advanced or Metastatic Colorectal Cancer. Record updated 2026-09-25.
Sponsored by Janssen Research & Development, LLCFull details on ClinicalTrials.gov → - recruitingNCT05513716
Molecular Characterisation of Colorectal Cancer Peritoneal Metastases
This project aims to characterise the tumour cell and tumour microenvironment of colorectal cancer peritoneal metastases, understand molecular changes leading to colorectal peritoneal metastasis, identify potential biomarkers and novel treatment strategies.
Listed by the study for Colorectal Cancer Metastatic. Record updated 2025-01-01.
Sponsored by The Christie NHS Foundation TrustFull details on ClinicalTrials.gov → - recruitingNANCT06220058
Comparing Polypropylene Mesh and "Small Bites" Technique in Emergency Colorectal Surgery's Midline Laparotomy Closure. Study for Incisional Hernia Prevention.
The 2023 World Journal of Emergency Surgery guidelines couldn't provide a recommendation for emergency abdominal wall closure due to insufficient consensus (\>80% required). Available evidence, predominantly retrospective and heterogeneous, lacks differentiation between urgent...
Listed by the study for Colorectal Cancer. Record updated 2024-10-08.
Sponsored by Fernandez ZamoraFull details on ClinicalTrials.gov →
Data from ClinicalTrials.gov, retrieved 2026-10-12. Study sponsors write and update their own records there, including the recruitment status shown here, and the U.S. government does not review or approve every study listed. A trial showing up here is not a recommendation and not a determination that anyone qualifies. Eligibility is decided by the trial's own doctors.
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Add whatever you know: an age, a city, a mutation from a pathology report. We'll narrow the list to trials that fit. Describe it in your own words.
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Common questions
- Is this colorectal cancer trial finder really free?
- Yes. You describe the situation, we search ClinicalTrials.gov and show what matches. No account, no payment, no email required. Nothing you type is saved.
- Does showing up here mean the patient qualifies?
- No. A listing here is not a recommendation, and the U.S. government does not review or approve every study on ClinicalTrials.gov. These are trials worth asking your care team about. Every trial has detailed eligibility criteria that the trial's own doctors evaluate, and many depend on test results and treatment history that only your medical team knows in full.
- How current is this list?
- The trials come directly from ClinicalTrials.gov and are refreshed daily, with the retrieval date shown under the list. Each study record is written and kept up to date by that study's own sponsor, so the recruitment status is what the sponsor last reported. Each result links to the full, live record, and the finder above always runs a fresh search when you use it.
- What should I do with a trial that looks promising?
- Bring it to your oncologist or care team, and mention the NCT number (the ID that starts with NCT). They can tell you whether it is a genuine fit and refer you to the trial site.
Found trials worth discussing? Keep them next to the records.
The next step is a conversation with the care team, and that goes better when the scans, labs, and trial details live in one place everyone in the family can see. That's what KeptWell is: the binder, but it understands what's inside.
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